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C•Dots - Development building sustainable investments

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  • Ноутбуки Packard Bell
  • Carbon dots: synthesis, formation mechanism, fluorescence origin and sensing applications
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Only 1 left. Dots-c-262g32nuw Merged transmission and fluorescence left and fluorescence right imaging of HK-2 cells after In summary, the observed anticancer activity of the as-synthesized spice-derived C-dots, in particular those from turmeric and black pepper, along with their preferential accumulation in glioblastoma cells, and excellent tolerability by non-cancerous cells, suggest great potential for a biomedical applicability of the spice C-dots as theranostic agents. Further studies would be necessary to achieve a better understanding of the mechanism of action of these C-dots, and to clarify the pathways involved in the toxicity in both cell types. Black pepper C-dots showed the most noticeable effect on the LN cells. Thus, in order to elucidate whether the black pepper C-dots effect might be attributed to the presence of molecules existing in the starting material, mass spectrometry measurements of black pepper C-dots were performed.

Thus, the reduction of cancer cell viability produced by the assayed spice-derived C-dots could be attributed to the components of the spices employed for the synthesis. Dots-c-262g32nuw results of this study demonstrate that C-dots showing similar physicochemical characteristics can be synthetized from diverse spices using a one-pot green hydrothermal method.

Packard Bell dot DOTS-C-262G32nuw (NU.C0CES.007)

Cinnamon, red chilli, turmeric and black pepper C-dots have shown high fluorescence quantum yields of Additionally, the dots-c-262g32nuw values of negative zeta potential that all the spice-based C-dots presented ensure a great colloidal stability in biological media. The four different spice-based C-dots have been systematically evaluated dots-c-262g32nuw study the in vitro toxicity to human cancer cells.


The C-dots exhibit an interesting differential cytotoxicity in cancerous and non-cancerous human cells, which should be further explored. This differential cytotoxicity depends from the spice from which the C-dots were synthesized. An evident concentration-dependent reduction in cell viability was observed for LN cells after 24 h of exposure to increasing concentrations of each Dots-c-262g32nuw type. Our preliminary results showed that this effect might be attributed to the presence of active molecules within the C-dot nanostructure, and more studies should be performed to understand the mechanism of action. Although it is of paramount importance to understand the complex nature of the C-dots, currently there is no agreement in the principles of the emission routes of the C-dots.

A detailed investigation using non-conventional spectroscopic techniques would help to shed light on some missing information concerning C-dots. This information would allow for dots-c-262g32nuw better comprehension of how the C-dots interact with cancerous and non-cancerous cells with a selective cytotoxic effect, and more applications, including photodynamic therapy, could be devised. Finally, results from the experiments allow us to unequivocally affirm that the C-dots synthesized here have a strong potential for bioanalytical and clinical applications. First, results obtained from fluorescence confocal microscopy studies have demonstrated that the C-dots from spices can be easily tracked when incorporated into cells, because their self-fluorescence is clearly different from the background of the medium.

The excellent photoluminescence properties can be exploited for in vitro imaging applications, avoiding interferences from undesirable autofluorescence of cells significantly affecting conventional fluorophores. Try again?Product type: Netbook.


Brand: Packard Bell. Series: dot dots-c-262g32nuw. Model: DOTS-CG32nuw. Market region: Europe, Middle East, Africa.


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